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10.2 Mechanisms and epidemiology Nociplastic pain stems from central sensitization, involving abnormal pain processing in the peripheral and central nervous systems, leading to increased sensitivity and reduced inhibition

Although the absolute amount of prolactin secreted by adipose tissue is significantly lower than that produced by the anterior pituitary gland, the large number of adipocytes (especially in highly obese individuals) suggests that adipose-derived prolactin may significantly contribute to systemic prolactin production ( de novo , with its expression and secretion strongly stimulated by cyclic adenosine monophosphate (cAMP) enhancers ( Therefore, we hypothesized that increased adipose tissue hypertrophy and quantity in obese individuals, leading to increased prolactin release, may ultimately result in hyperprolactinemia

The science of fibromyalgia

The metabolism of Vitamin B is critical in converting food into energy, making Vitamin B12 one of the key players in combating fatigue